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While the interactions can be pharmacodynamic in nature, synthroid price kava kava has been reported to inhibit many CYP isozymes (ie, CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A9/11) and important pharmacokinetic interactions with CNS-active agents that undergo oxidative metabolism via these CYP isozymes are also possible?